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KMID : 0360419800160010009
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Korean Journal of Pharmacology
1980 Volume.16 No. 1 p.9 ~ p.14
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The Studies on Glycogenolytic Adrenergic Receptor in Rat
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Abstract
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To evaluate the adrenergic receptors for glycogenolytic responses to catecholamine, the blood glucose level, liver glycogen content and muscle glycogen level in rats were studied with treatment of epinephrine, norepinephrine and isoproterenol. In addition, to study the possibility of interconversion of adrenergic receptors, the effects of catecholamines in feeding animal were compared with those in fasting animal.
The results are summarized as follow;
1) Epinephrine and norepinephine showed dose dependent increase of blood glucose level but the effect of isproterenol was not significant.
2) The prandial states of animal did not influence on effects of catecholamines on blood glucose level.
3) Liver glycogen contents were lowered by epinephrine or by norepinephrins but effect of isoproterenol was not significant.
4) Glycogen content of skeletal muscle was significantly lowered by isoproterenol and. epinephrine shifted the dose-response curve to right, but the effect of norepinephrine was not significant.
5) The effects of epinephrine and norepinephrine on blood glucose were significantly blocked by ergotamine but not by propranolol.
These results indicate that the glycogenolytic response to adrenergic agents in rat is mediated by an alpha-receptor in liver and by a beta-receptor in skeletal muscle.
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